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Most of what transcription factors and restriction enzymes do happens in the major groove

which is why it remains preferred for long-term loss-of-function studies in cell lines and animal models

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DNA cufflinks | silver pp_DNA rheumatoid arthritisDNA cufflinks sterling silver DNA is the molecule that everyone in the room has heard of and that fewer people in the room can sketch from memory. Watson and Crick's 1953 structure paper is among the most cited single biology articles ever published. The double helix has earned the wear at the cuff of a formal shirt. The Science Behind the Double Helix The Watson Crick structure paper was published in Nature in April 1953, but the genetic code took